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Rhoden EL, Morgentaler A. Risks of testosterone-replacement remedy and suggestions for monitoring. Testosterone substitute in hypogonadal men with angina improves ischaemic threshold and high quality of life. Ajayi AAL, Mathur R, Halushka PV. Testosterone increase human platelet thromboxane A2 receptor density and aggregation responses.
- The biggest threat of erythrocytosis happens with injectable forms of testosterone compared with transdermal preparations, particularly in supraphysiologic doses.
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- An improve of up to 44% of the baseline hematocrit has been reported .
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Moreover, a part of endothelial dysfunction has been proposed, which may contribute to irregular vessel reactivity. However, testosterone in physiologic doses might even be beneficial in patients with angina , have higher ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood circulate in males with established coronary artery illness . Therefore, an interaction of endogenous factors of the patient’s threat profile in addition to the testosterone dosing could additionally be issues of whether antagonistic events happen.
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We report a case of an acute ST-segment elevation myocardial infarction in a affected person with traditional cardiac threat factors using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person also had polycythemia, doubtless secondary to high-dose testosterone. The patient underwent successful percutaneous intervention of the best coronary artery. Physicians and sufferers should pay attention to the clinical consequences of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996).
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Erythrocytosis has been reported as a possible impact of testosterone, which can be beneficial in patients with anemia. The best danger of erythrocytosis occurs with injectable forms of testosterone in contrast with transdermal preparations, especially in supraphysiologic doses. An increase of up to 44% of the baseline hematocrit has been reported .
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